Advancements in Intra‐Articular Drug Delivery Systems for Osteoarthritis Therapy

ABSTRACT Osteoarthritis (OA) treatment faces critical challenges of rapid clearance and short therapeutic duration following conventional intra‐articular (IA) drug injections. To address these limitations, researchers have developed novel carrier‐based delivery systems that enable precise drug localization and sustained release through material engineering and controlled‐release technologies. These innovative strategies significantly enhance drug retention within the joint cavity while reducing systemic exposure and associated side effects. This review systematically summarizes recent advancements in IA delivery systems, with a focus on the design principles of different carriers, as well as their applications in improving therapeutic outcomes. By providing a comprehensive analysis of the current research landscape, this review establishes a theoretical foundation for developing more effective OA treatment strategies.