Bioresorbable Systems in Healthcare for Transient Sensing and Therapeutic Interventions

ABSTRACT Transient bioresorbable systems operate only during the clinically indicated window and then dissolve into benign products, eliminating explantation. By matching device presence to the days to weeks period after surgery or intervention, they reduce exposure to anesthesia, reentry trauma, and risks of infection, bleeding, and wound dehiscence, while shortening recovery and lowering costs. This review surveys sensing and therapeutic platforms that use bioresorbable polymers, metals, and silicon based materials to provide structural, conductive, dielectric, and semiconducting functions. Physical sensing of pressure and temperature employs capacitive, piezoelectric, triboelectric, and resistive transduction, together with passive inductor capacitor resonant readouts. Chemical sensing of potential of hydrogen leverages fluorescence based optics, radio frequency hydrogel resonators, and ultrasound readable shape adaptive materials. Therapeutic examples include radio frequency or ultrasound powered electrical stimulation for nerve regeneration or analgesia, temporary cardiac pacing, and localized drug delivery via wireless heating reservoirs or sealed on demand valves. We present a design map linking material chemistry, thickness and geometry, and encapsulation to service lifetime, supported by accelerated soak tests and diffusion and Arrhenius models of defect driven leakage. We also offer cross modal rules and checklists for translational readiness, including standardized reporting and validation from models to living organisms.