Cover Feature: Structural Characterization and AI‐Enhanced Modeling of a Broadly Neutralizing Camelid Antibody Against SARS‐CoV‐2 Variants (Adv. Therap. 1/2026)

The cover image of the Research Article (DOI: 10.1002/adtp.202500244) by Katja Hanack, Ramasamy Paulmurugan, and co-workers shows the outcome of a multi-institutional collaborative effort developing a novel camelid antibody (B10) targeting SARS-CoV2 with wide spectrum neutralizing effect. This study systematically characterized the functional neutralizing effect of this antibody using epitope mapping, peptide fragment inhibition, neutralization, in silico molecular docking, and AI-directed structural design, to reveal the interaction of B10 with the Spike trimer from different variants. This newly generated antibody could be a potential candidate to efficiently neutralize a wide range of current and future variants of SARS-CoV-2 for broad clinical applications.