Stereodivergent Access to Aliphatic Nitro Compounds Bearing Multi‐Contiguous Stereocenters via Sequential Catalysis
Abstract
Herein, we report a highly efficient synthesis of aliphatic nitro compounds bearing multi-contiguous stereocenters in good yields (up to 72%) with excellent diastereo- and enantio-selectivities (up to 12:1 dr, and >99% ee) by combining copper-catalyzed asymmetric conjugate addition of dialkylzinc reagents to nitroalkenes with iridium-catalyzed asymmetric allylic substitution reaction. Stereodivergent construction of nonadjacent stereocenters (1,3-positions) has been achieved by combining two chiral catalysts with different enantiomers. By first introducing a chiral center at the β-position of the nitro group, highly diastereoselective control has been achieved in iridium-catalyzed allylic substitution reaction of prochiral nitro compounds.
Fields of Study & Subjects
Asymmetric Synthesis and Catalysis
Asymmetric Hydrogenation and Catalysis
Catalytic C–H Functionalization Methods
Publication details
- Journal / source
- Advanced Science
- Publisher
- Wiley
- Volume
- 13
- Issue
- 14
- Pages
- e19142–e19142
- Publication date
- 3 February 2026
- Language
- EN