A LDH‐Based Supramolecular Photosensitizer‐Functionalized Bioactive Glass Scaffold for Integrated Postoperative Osteosarcoma Recurrence Prevention and Bone Regeneration

ABSTRACT Layered double hydroxide (LDH)‐based materials have been explored as efficient photosensitizers for photodynamic therapy (PDT) or functional agents for bone regeneration, holding great promise in the synergistic PDT‐mediated osteosarcoma treatment and bone reconstruction. Herein, we report the functionalization of 5‐iodoisophthalic acid (I‐IPA)‐intercalated MgZnAl‐LDH onto bioactive glass scaffold (BGS) to construct a bifunctional composite scaffold (BGS/I‐LDH) for integrated osteosarcoma treatment and bone regeneration. The surface functionalization of I‐LDH onto BGS confers BGS/I‐LDH high‐efficiency reactive oxygen species generation performance under 1270 nm laser irradiation, resulting in a singlet oxygen quantum yield up to 1.53, which is significantly superior to that of previously reported NIR‐excited PSs. Moreover, thanks to the sustained release of Mg 2+ and Zn 2+ ions from I‐LDH, BGS/I‐LDH exhibits exceptional anti‐osteosarcoma and osteogenic properties with 3.8‐fold bone volume, 3.0‐fold bone mineral density, and 11.4‐fold new bone mass increments compared with the pristine BGS, which is remarkably more preponderant than other previously reported modified BGS.