A Conformal Wearable Ultrasound Bioelectronics for Mechanotherapy Reprogramming of Fibroblast Plasticity via Wnt‐FGF10 Axis to Overcome Fibrotic Healing in Urethral Regeneration

Advanced Science 2026 Open access

Read full text
Authors: Mengmeng Yu, Xingxuan Zhang, Huan Zhang, Yi-Xiang Wang, Fang Chen, Xiaojun Cai, Y J Huang, Yuanyi Zheng
DOI: 10.1002/advs.202600037
Cited by: 1
References: 27

Abstract

ABSTRACT Postoperative fibrotic complications persistently challenge urethral reconstruction due to dysregulated stromal repair and poor graft integration. Conventional rigid ultrasound transducers lack anatomical conformity on dynamic tissues, limiting therapeutic efficacy. Here, we introduce a conformal, wearable low‐intensity pulsed ultrasound (LIPUS) bioelectronic system that overcomes these constraints via controlled adhesion printing and liquid metal interconnects. This low‐cost (

Fields of Study & Subjects

Tissue Engineering and Regenerative Medicine Pelvic floor disorders treatments Ultrasound and Hyperthermia Applications

Publication details

Journal / source
Advanced Science
Publisher
Wiley
Volume
13
Issue
24
Pages
e00037–e00037
Publication date
16 February 2026
Language
EN