HERV‐K TM Subunit Elicits CD8 + T Cell Anergy and Tumor Immune Evasion via Targeting CD3 Coreceptor ε in AML and PDAC (Adv. Sci. 1/2026)

Advanced Science 2026 Open access

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Authors: Mengyuan Li, Shuwen Zheng, Qinyuan Gong, Zhaoxing Wu, Wen Lei, Wanyue Cao, Ping Wang, Xuzhao Zhang, Wenbin Qian, Yun Liang, Ying Lu, Fenglin Li
+2 more Qi Zhang, Rongzhen Xu
DOI: 10.1002/advs.73175
Cited by: 0

Abstract

Immune Therapies In their Research Article (DOI: 10.1002/advs.202417432), Rongzhen Xu, Qi Zhang, Mengyuan Li, and co-workers identify the human endogenous retrovirus-K envelope transmembrane subunit (K-TM) as a novel viral immune checkpoint that drives CD8+ T cell anergy and promotes immune evasion in acute myeloid leukemia and pancreatic ductal adenocarcinoma. K-TM binds directly to the CD3ε ITAM domain, suppresses TCR signaling, and impairs antitumor immunity. Targeting K-TM reverses T cell dysfunction and inhibits tumor growth, revealing a conceptually new target for immune therapies.

Fields of Study & Subjects

interferon and immune responses Immunotherapy and Immune Responses Multiple Myeloma Research and Treatments

Publication details

Journal / source
Advanced Science
Volume
13
Issue
1
Publication date
1 January 2026
Language
EN