A Minimally Invasive Framework Reveals Region‐Specific Cerebrovascular Remodeling in Aging Using Intravital Functional Ultrasound Imaging and Ultrasound Localization Microscopy (fUS‐ULM) (Adv. Sci. 1/2026)

Advanced Science 2026 Open access

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Authors: Sharon Negri, Ádám Nyúl‐Tóth, Madison Milan, Eva Troyano‐Rodriguez, Sherwin Tavakol, Jennifer Ihuoma, Zeke Reyff, Rakesh Rudraboina, Rafał Gulej, Raymond Jang, Anna Csiszar, Zoltan I. Ungvari
+5 more Audrey C. A. Cleuren, David M. Miller, Andriy Yabluchanskiy, Mickael Tanter, Stefano Tarantini
DOI: 10.1002/advs.73176
Cited by: 0

Abstract

Ultrasound Localization Microscopy The cover image depicts functional ultrasound localization microscopy (ULM) revealing the brain's intricate microvascular networks in youth and aging. Red and blue hemispheres contrast robust perfusion and dense capillary architecture in young brains with rarefied, sluggish flow in aged ones. Microbubbles trace these pathways, illuminating how aging alters cerebrovascular integrity and hemodynamic function at micron resolution. More details can be found in the Research Article by Stefano Tarantini and co-workers (DOI: 10.1002/advs.202510754).

Fields of Study & Subjects

Ultrasound Imaging and Elastography Cerebrovascular and Carotid Artery Diseases Neurological Disease Mechanisms and Treatments

Publication details

Journal / source
Advanced Science
Volume
13
Issue
1
Publication date
1 January 2026
Language
EN