Calhm6 Governs Macrophage Polarization Through Chp1‐Camk4‐Creb1 Axis and Ectosomal Delivery in Inflammatory Responses (Adv. Sci. 1/2026)

Advanced Science 2026 Open access

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Authors: Yanlong Xin, Xiaofan Xiong, Yan Zhang, Siyu Zhang, Shuting Zhang, Yu Yang, Yingxue Liang, Lulu Zang, Xi Chen, Wenjuan Li, Issam Halalmeh, Rui Zhou
+3 more Zongfang Li, Haowen Liu, Jing Geng
DOI: 10.1002/advs.73177
Cited by: 0

Abstract

Ectosomal Calhm6 in Sepsis High mortality in sepsis patients emphasizes the urgent need to control acute inflammation. The Research Article by Jing Geng, Yanlong Xin, Xiaofan Xiong, and co-workers (DOI: 10.1002/advs.202502395) identifies the ion channel Calhm6 is produced by M1-like macrophages and delivered via ectosomes. The cover artwork illustrates the man (M1-like macrophage) releases the hero (Calhm6) through the ectosomes (backpack) and cooperates with other helpers (M2-like macrophage) to fight the monster (acute inflammation).

Fields of Study & Subjects

Immune cells in cancer Phagocytosis and Immune Regulation Cell Adhesion Molecules Research

Publication details

Journal / source
Advanced Science
Volume
13
Issue
1
Publication date
1 January 2026
Language
EN