Single Cell and Spatial Transcriptomics Define a Proinflammatory and Profibrotic Niche After Kidney Injury (Adv. Sci. 2/2026)

Advanced Science 2026 Open access

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Authors: Li Li, Jinlin Liao, Yuxi Zhang, Zifu Yao, Junxin Huang, Kejia Wu, Lu Li, Yiling Peng, Haili Zhu, Xue Hong, Xi Liu, Lili Zhou
+3 more Fan Fan Hou, Haiyan Fu, Youhua Liu
DOI: 10.1002/advs.73179
Cited by: 0

Abstract

Proinflammatory and Profibrotic Niche After Kidney Injury On this cover, layered terraces represent kidney spatial layers, with circular niches in the outer medulla where blooming water hyacinths symbolize tenascin C. These flowers attract apple snails as macrophages, depicting how niche-specific microenvironments drive inflammation and fibrosis revealed by single-cell and spatial transcriptomics profiling in the Research Article by Li Li, Haiyan Fu, Youhua Liu, and co-workers (DOI: 10.1002/advs.202503691).

Fields of Study & Subjects

Single-cell and spatial transcriptomics Acute Kidney Injury Research Neutrophil Myeloperoxidase and Oxidative Mechanisms

Publication details

Journal / source
Advanced Science
Volume
13
Issue
2
Publication date
1 January 2026
Language
EN