An Aptamer‐Based EXACT Anticoagulant as a Sustainable, Animal‐Free Alternative to Unfractionated Heparin (Adv. Sci. 4/2026)

Advanced Science 2026 Open access

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Authors: Haixiang Yu, George A. Pitoc, Manqi Zhang, Jeffrey Clancy, James W. Frederiksen, Amy C. Yan, Samuel Francis, Rebecca D Sullenger, Rachel E. Rempel, Susannah Gammell, Jillian Caiazzi, Bruce A. Sullenger
DOI: 10.1002/advs.73397
Cited by: 0

Abstract

Unfractionated Heparin A billion pigs are utilized per year to meet the world's demand for heparin, a WHO essential medicine used for many cardiovascular indications. Creating sustainable anticoagulant drugs that can replace heparin is challenging. In their Research Article (DOI: 10.1002/advs.202509867), Haixiang Yu, Bruce A. Sullenger, and co-workers describe a novel approach that employs an EXACT inhibitor to target both the EXosite and ACTive site on thrombin.

Fields of Study & Subjects

Blood Coagulation and Thrombosis Mechanisms Heparin-Induced Thrombocytopenia and Thrombosis Advanced biosensing and bioanalysis techniques

Publication details

Journal / source
Advanced Science
Volume
13
Issue
4
Publication date
1 January 2026
Language
EN