Integrin‐Piezo1 Axis Drives ECM Remodeling and Invasion of 3D Breast Epithelium (Adv. Sci. 5/2026)

Advanced Science 2026 Open access

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Authors: Kabilan Sakthivel, Anna Kotowska, Zhimeng Fan, Ellen Juel Pørtner, Catherine L.R. Merry, Pontus Nordenfelt, Adam Cohen Simonsen, Amanda J. Wright, Vinay Swaminathan
DOI: 10.1002/advs.73402
Cited by: 0

Abstract

3D Mechanotransduction The cover image shows mammary acini progressing from polarized spheres to invasive, tumor-like structures as their surrounding matrix stiffens. Using an in-situ stiffening hydrogel system, Vinay S Swaminathan and co-workers demonstrate that ECM stiffening around normal 3D mammary acini activates integrin-FAK-Piezo1 mechanosignaling, triggering basement-membrane rupture, fibronectin remodelling, and the emergence of coordinated, invasive cell collectives. More details can be found in the Research Article (DOI: 10.1002/advs.202509932).

Fields of Study & Subjects

Cellular Mechanics and Interactions Cell Adhesion Molecules Research Cancer Cells and Metastasis

Publication details

Journal / source
Advanced Science
Volume
13
Issue
5
Publication date
1 January 2026
Language
EN