Depletion of Sorcs3 Activates Totipotency in Mouse Embryonic Stem Cells by Modulating Key Signaling Pathways (Adv. Sci. 7/2026)

Advanced Science 2026 Open access

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Authors: Wenhao Zhang, Xinyu Mao, Yu He, Qingshen Jia, Yiding Zhao, Xiaomeng Dai, Xiaoyan Li, Shengyi Sun, Xiaoyan Sheng, Dan Ding, Yuan Shi, Qian Gao
+1 more Ling Shuai
DOI: 10.1002/advs.73665
Cited by: 0

Abstract

Depletion of Sorcs3 Activates Totipotency In their Research Article (DOI: 10.1002/advs.202509151), Yuan Shi, Qian Gao, Ling Shuai, and colleagues report that knocking out sorcs3 or inhibiting three key pathways can efficiently activate the totipotency of stem cells. The hall of totipotency is a lofty and desirable goal, and the path to it is fraught with challenges. The findings of this study are like a shortcut to aid the climb toward totipotency.

Fields of Study & Subjects

Pluripotent Stem Cells Research Developmental Biology and Gene Regulation Mesenchymal stem cell research

Publication details

Journal / source
Advanced Science
Volume
13
Issue
7
Publication date
1 February 2026
Language
EN