Epstein‐Barr Virus Expressed Long Non‐Coding RNA ( lncBART s) Regulate EBV Latent Genome Replication (Adv. Sci. 8/2026)

Advanced Science 2026 Open access

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Authors: Jiayan Liu, Dittman Lai‐Shun Chung, Larry Ka-Yue Chow, Shuo Han, Wenkai Yi, Conor J. Cremin, Yajin Liao, Pui Wang, Bobo Wing-Yee Mok, Mingfang Ji, Jian Yan, Wei Dai
+1 more Honglin Chen
DOI: 10.1002/advs.73824
Cited by: 0

Abstract

Epstein-Barr Virus The tethering of the EBV episome to the chromosome is critical for the replication of the latent genome in infected cells. In their Research Article (DOI: 10.1002/advs.202507286), Wei Dai, Honglin Chen, and co-workers demonstrate that EBV-encoded lncBARTs (red) interact with BRD4 and CTCF to facilitate the attachment of the oriP region of the EBV episome to the chromosome. The interaction between lncBARTs-BRD4 and chromosome leads to the epigenic alteration of genome and promote oncogenesis.

Fields of Study & Subjects

Viral-associated cancers and disorders Cancer-related molecular mechanisms research Genomics and Chromatin Dynamics

Publication details

Journal / source
Advanced Science
Volume
13
Issue
8
Publication date
1 February 2026
Language
EN