Redox‐Responsive Polymeric Nanocapsules for Enhanced Tumor‐Targeted Delivery of Antimicrobial Peptides

Advanced Science 2026 Open access

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Authors: Lin Tang, Yajian Li, Xiaoyin Lv, Jianmei Guo, Yijia Zhang, Yuqi Lin, Kaili Nie, Jian Zeng, Mengya Zhang, Qiong Dai
DOI: 10.1002/advs.74480
Cited by: 1
References: 30

Abstract

Antimicrobial peptides (AMPs) hold promise as anticancer agents but suffer from proteolytic instability, systemic toxicity, and hemolysis. Here, we report a modular redox-responsive polymeric nanocapsule platform for enhanced tumor-targeted AMP delivery. Using melittin (MEL) as a stringent model, disulfide-crosslinked nanocapsules (nMEL) remain stable and inert under physiological conditions (

Fields of Study & Subjects

Nanoplatforms for cancer theranostics Antimicrobial Peptides and Activities Cancer Research and Treatments

Publication details

Journal / source
Advanced Science
Publisher
Wiley
Volume
13
Issue
24
Pages
e74480–e74480
Publication date
19 February 2026
Language
EN