Humanized and Charge‐Optimized CSPG4‐Specific CAR‐T Cells show Enhanced Efficacy against Head and Neck Squamous Cell Carcinoma (Adv. Sci. 35/2026)

Humanized and Charge-Optimized CSPG4-Specific CAR-T Cells The cover depicts a “scientific hammer of Thor” as a metaphor for the humanized and charge-optimized CSPG4 CAR. A stylized murine symbol at the hammer's core represents the grafted CDRs conferring tumor specificity. A strong arm wielding the hammer channels DNA strand patterns to illustrate humanized framework construction, while lightning converging on the hammer depicts surface charge optimization. This combined force strikes a CSPG4 covered tumor mountain, visualizing the rational engineering strategy that enhances CAR efficacy. More details can be found in the Research Article by Peijie He, Haitao Wu, Haopeng Wang, Jian Chen, and co-workers (DOI: 10.1002/advs.202519746).