Noninvasive Focal Gene Delivery into the Cerebellum of Non‐Human Primates using Focused Ultrasound (Adv. Sci. 37/2026)

Advanced Science 2026 Open access

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Authors: Noelia Esteban-García, José A. Pineda-Pardo, Inés Trigo‐Damas, Marta Gutiérrez, Marta Castillo-Ortiz, Megan Carrillo, Alejandro Reinares-Sebastián, Víctor Medina-Chavarrías, Itay Rachmilevitch, Masahiko Takada, José A. Obeso, Javier Blesa
DOI: 10.1002/advs.76113
Cited by: 1

Abstract

Noninvasive Focal Gene Delivery Drug delivery to the brain is limited by the blood-brain barrier. In their Research Article (DOI: 10.1002/advs.75307), José A. Obeso, Javier Blesa, and co-workers demonstrate successful barrier opening and focal delivery of adeno-associated viral vectors to the cerebellum after systemic injection using low-intensity focused ultrasound in macaques, enabling noninvasive gene therapy approaches.

Fields of Study & Subjects

Ultrasound and Hyperthermia Applications Virus-based gene therapy research Nerve injury and regeneration

Publication details

Journal / source
Advanced Science
Publisher
Wiley
Volume
13
Issue
37
Publication date
1 July 2026
Language
EN