RHINO: An Integrative Multi‐Omics Framework Linking Circadian Physiology to Precision Medicine (Adv. Sci. 49/2026)

Rhythmic Interacting Network for Multi-Omics Circadian rhythms shape human physiology, and their disruption influences disease risk and therapeutic response. However, the rhythmic and druggable genome remains largely unexplored. In their Research Article (DOI: 10.1002/advs.76371), Leng Han, Dongyin Guan, and co-workers present RHINO (RHythmic Interacting Network for multi-Omics), an AI-powered web portal that integrates ten multi-omic layers, disease, and drug-target data across tissues and species to expand the landscape of rhythmic therapeutic targets. On the cover, a luminous rhinoceros stands at the boundary of day and night, as warm and cool streams of circadian multi-omics data converge and crystallize across its honeycombed body. The artwork symbolizes RHINO as an integrated, living network attuned to the oscillations of the biological clock. Cover credit: Lan-Tao Gou (Shanghai BioPaint Studio).