The Role of the Gut Microbiota in Allogeneic Hematopoietic Cell Transplantation
Abstract
Allogeneic hematopoietic cell transplantation (allo-HCT) is an effective treatment for patients with high-risk hematologic malignancies. Over the last decade, gut microbiota composition during allo-HCT has been associated with patients' outcomes. Treatment-related factors, in particular the use of broad-spectrum antibiotics and the conditioning regimen, frequently induce gut dysbiosis, which is associated with immune dysregulation, toxicity, and adverse outcomes, particularly after allo-HCT. Microbial metabolites further modulate immune responses and therapeutic efficacy. Emerging microbiota-targeted strategies-including antibiotic stewardship, nutritional interventions, probiotics, fecal microbiota transplantation, and postbiotics-show promise in reducing graft-versus-host disease, controlling inflammation, and improving treatment responses.
Fields of Study & Subjects
Gut microbiota and health
Neutropenia and Cancer Infections
Clostridium difficile and Clostridium perfringens research
Publication details
- Journal / source
- American Journal of Hematology
- Publisher
- Wiley
- Volume
- 101
- Issue
- 8
- Pages
- 1980–1996
- Publication date
- 12 May 2026
- Language
- EN