Recent Advances in Epoxide Deoxygenation to Alkenes: Catalyst Classes, Mechanistic Insights, and Future Perspectives

ABSTRACT Deoxygenation of epoxides to alkenes is a valuable transformation in organic synthesis that enables the formation of carbon–carbon double bonds (alkenes or olefins) from epoxides. This reaction offers an alternative strategy for the interconversion of alkene stereoisomers via epoxide formation and stereoinvertive deoxygenation. This review summarizes advancements in epoxide deoxygenation from 2010 to the present, organized by catalytic platforms, including homogeneous transition‐metal catalysis, heterogeneous transition‐metal catalysis, transition‐metal‐free protocols, photochemical and electrochemical approaches, and biocatalytic transformations. Mechanistic insights are emphasized, including the role of reductants and catalysts as well as stereochemical outcomes. A brief outlook is presented on the challenges and opportunities for advancing sustainable, stereospecific epoxide deoxygenation.