Iodine‐Mediated [2+2+1+1] Annulation Using N , N ‐Dimethylformamide as a One‐Carbon Synthon: Access to Pyridine and Triazine Scaffolds

Asian Journal of Organic Chemistry 2026

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Authors: Kamal Kant, Reetu Reetu, Arup K. Kabi, Nayyef Aljaar, Susanta Ghanta, Chandi C. Malakar, Reda A. Haggam
DOI: 10.1002/ajoc.70334
Cited by: 1
References: 31

Abstract

ABSTRACT A metal‐free approach to the synthesis of pyridine and 1,3,5‐triazine derivatives is attempted under the influence of molecular iodine, utilizing a [2+2+1+1] annulation strategy. This annulation strategy operates effectively with N , N‐ dimethylformamide (DMF) as a C1 Source under mild reaction conditions, yielding the corresponding products in high yields ranging from 68% to 87%. A detailed mechanistic proposal is presented and supported by density functional theory calculations, which corroborate key intermediates and the iodine‐mediated C1‐incorporation pathway.

Fields of Study & Subjects

Catalytic C–H Functionalization Methods Chemical Reaction Mechanisms Synthesis and Characterization of Heterocyclic Compounds

Publication details

Journal / source
Asian Journal of Organic Chemistry
Publisher
Wiley
Volume
15
Issue
2
Publication date
1 February 2026
Language
EN