Transition‐Metal‐Free LiO t Bu‐Promoted Three‐Component Reaction for Efficient Synthesis of Triazolyl (Thio)ureas

Asian Journal of Organic Chemistry 2026

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Authors: W. J. Wang, Chunpeng Qiu, Zhihao Zuo, Younan Wang, Jingyu Wang
DOI: 10.1002/ajoc.70375
Cited by: 3
References: 49

Abstract

ABSTRACT A transition‐metal‐free LiO t Bu‐promoted three‐component reaction for efficient synthesis of the triazolyl (thio)ureas has been reported. This reaction proceeded via the cyclocondensation of nitriles and azides in the presence of a base, followed by the interception of the triazolamine and triazole nitrogen anion intermediate using (thio)carbamoylimidazoles. This method is characterized by being transition‐metal‐free, a broad substrate scope, and mild reaction conditions.

Fields of Study & Subjects

Click Chemistry and Applications Sulfur-Based Synthesis Techniques Catalytic C–H Functionalization Methods

Publication details

Journal / source
Asian Journal of Organic Chemistry
Publisher
Wiley
Volume
15
Issue
3
Publication date
1 March 2026
Language
EN