Blood‐based Alzheimer's disease biomarkers and cognitive trajectories in older people with HIV with undetectable viral loads

Alzheimer s & Dementia 2026 Open access

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Authors: Akarin Hiransuthikul, Poosanu Thanapornsangsuth, Watayuth Luechaipanit, Thanaporn Haethaisong, Sasiwimol Ubolyam, Tanakorn Apornpong, Win Min Han, Stephen J. Kerr, Anchalee Avihingsanon, HIV‐NAT 006 and 207 study team
DOI: 10.1002/alz.71101
Cited by: 4
References: 38

Abstract

INTRODUCTION: Cognitive impairment among people with HIV (PWH) remains common, yet underlying mechanisms remain unclear. Alzheimer's disease (AD) is the leading cause of dementia, and blood-based biomarkers offer a promising diagnostic alternative. We evaluated phosphorylated-tau 217 (p-tau217), neurofilament light (NfL), and glial fibrillary acidic protein (GFAP) as predictors of cognitive decline among virologically suppressed older PWH. METHODS: Thai PWH aged ≥50 years with plasma viral loads

Fields of Study & Subjects

Dementia and Cognitive Impairment Research HIV Research and Treatment Alzheimer's disease research and treatments

Publication details

Journal / source
Alzheimer s & Dementia
Publisher
Wiley
Volume
22
Issue
1
Pages
e71101–e71101
Publication date
1 January 2026
Language
EN