ARIAs are not random: A posterior and border‐zone vascular vulnerability model
Abstract
HIGHLIGHTS: ARIA often shows posterior and watershed predominance, indicating region-specific vascular vulnerability beyond amyloid burden alone. Reduced autoregulatory reserve in posterior territories may predispose to blood-brain-barrier disruption during anti-amyloid therapy. Watershed regions are hemodynamically fragile, lowering the threshold for vasogenic edema or microhemorrhage after amyloid mobilization. ARIA may represent a PRES-like neurovascular decompensation within an amyloid-compromised vascular bed.
Fields of Study & Subjects
Intracerebral and Subarachnoid Hemorrhage Research
Alzheimer's disease research and treatments
Dementia and Cognitive Impairment Research
Publication details
- Journal / source
- Alzheimer s & Dementia
- Publisher
- Wiley
- Volume
- 22
- Issue
- 3
- Pages
- e71304–e71304
- Publication date
- 1 March 2026
- Language
- EN