Metallaphotoredox‐Catalyzed Acceptorless Dehydrogenative Carbonylation Employing Benzylic C─H Bonds as Limiting Substrates

Angewandte Chemie 2026

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Authors: Ling Li, Chuqian Tang, Guangying Huang, Shengqing Zhu, Yuyang Bai, Lingling Chu
DOI: 10.1002/ange.9220846
Cited by: 1
References: 73

Abstract

ABSTRACT We report a visible light‐driven, metallaphotoredox‐catalyzed acceptorless dehydrogenative carbonylation of benzylic C─H bonds with carbon monoxide and nucleophiles. Enabled by a long‐chain diphosphine ligated nickel(II) bromide complex, this protocol uniquely employs C(sp 3 )─H bonds as limiting reagents under ambient temperature and CO atmosphere, affording esters and related carbonyls under oxidant‐free conditions with H 2 as the sole byproduct. The reaction exhibits broad substrate scope, tolerating diverse functional groups and complex bioactive scaffolds. Mechanistic studies are consistent with a pathway involving photoinduced hydrogen atom transfer and nickel‐mediated carbonylation.

Fields of Study & Subjects

Catalytic C–H Functionalization Methods Radical Photochemical Reactions Asymmetric Hydrogenation and Catalysis

Publication details

Journal / source
Angewandte Chemie
Publisher
Wiley
Volume
138
Issue
27
Publication date
12 May 2026
Language
EN