Outside Back Cover: Rhodopsin‐Mimicking Reversible Photo‐Switchable Chloride Channels Based on Azobenzene‐Appended Semiaza ‐Bambusurils for Light‐Controlled Ion Transport and Cancer Cell Apoptosis (Angew. Chem. Int. Ed. 3/2026)

Angewandte Chemie International Edition 2026 Open access

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Authors: Lei He, Yue Ma, Yang Zhang, Canhong Zhu, Feihu Yang, Yuancheng Ji, Shengda Liu, Hui Li, Jiayun Xu, Pengfei Zhang, Tengfei Yan, Ofer Reany
+1 more Junqiu Liu
DOI: 10.1002/anie.2025-m0501054600
Cited by: 0

Abstract

In the Research Article (e202519101), Tengfei Yan, Ofer Reany, Junqiu Liu, and co-workers present a reversible, light-controlled ON/OFF chloride channel based on azobenzene-functionalized semiaza-bambus[6]urils. These biomimetic systems achieve stimulus-responsive chloride transport through photoisomerization, demonstrating unprecedented controllability in both liposomal membranes and living cells. The (E)-isomer selectively enables chloride flux, induces significant mitochondrial and lysosomal disruption, and promotes apoptosis in cancer cells, while the (Z)-isomer remains inactive.

Fields of Study & Subjects

Photochromic and Fluorescence Chemistry Supramolecular Self-Assembly in Materials Supramolecular Chemistry and Complexes

Publication details

Journal / source
Angewandte Chemie International Edition
Volume
65
Issue
3
Publication date
6 January 2026
Language
EN