Magnesiation of Phenol Derivatives Catalyzed by a Rhodium─Aluminum Complex
Abstract
Here we describe the generation of aryl Grignard reagents from phenol derivatives via C─O bond activation cooperatively catalyzed by Rh─Al heterobimetallic complexes. We discovered that the electron-rich arylmagnesium reagents could be efficiently prepared from the corresponding aryl carbamates, whereas the π-extended arylmagnesium reagents were obtained from the corresponding aryl ethers. This methodology enables the efficient conversion of a broad range of phenol derivatives into the corresponding Grignard reagents, which can subsequently react with various electrophiles to yield a diverse array of organic compounds.
Fields of Study & Subjects
Catalytic Cross-Coupling Reactions
Coordination Chemistry and Organometallics
Catalytic C–H Functionalization Methods
Publication details
- Journal / source
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Volume
- 65
- Issue
- 12
- Pages
- e18631–e18631
- Publication date
- 8 February 2026
- Language
- EN