Bioorthogonally Activatable Chemiluminescence for the N ‐Methyl‐ d ‐aspartate Receptors Intravital Imaging

Angewandte Chemie International Edition 2026

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Authors: Simiao Cheng, Mingyue Zhang, Jian Zhang, Xilei Xie, Yong Li, Xueyu Dou, Xiaoyun Jiao, Yujie Tang, Xu Wang, Bo Tang
DOI: 10.1002/anie.202523648
Cited by: 2
References: 30

Abstract

The signal attenuation caused by skull/vertebrae remains a challenge in central nervous system (CNS) receptor imaging. Chemiluminescence (CL), free from external excitation, offers unparalleled tissue penetration in optical imaging. However, existing 1,2-dioxetane CL systems are shackled by two limitations: (i) short half-lives (

Fields of Study & Subjects

bioluminescence and chemiluminescence research Click Chemistry and Applications Nanoplatforms for cancer theranostics

Publication details

Journal / source
Angewandte Chemie International Edition
Publisher
Wiley
Volume
65
Issue
9
Pages
e23648–e23648
Publication date
19 January 2026
Language
EN