Outside Front Cover: Membrane‐Penetrating Molecular Device Based on a Triplex Containing Acyclic L‐Threoninol Nucleic Acid Functionalized with Cholesterol (Angew. Chem. Int. Ed. 9/2026)
Abstract
A membrane-penetrating molecular device composed of triplex containing cholesterol-modified acyclic L-threoninol nucleic acid (L-aTNA) is achieved. This device is applied to a reversible photo-triggered signal transduction system functioning on giant unilamellar vesicles. UV irradiation-induced release of DNA-based molecular signals into the GUV interior, which recovers after irradiation with visible light, as reported by Hiroyuki Asanuma, Keiji Murayama, and Kaifu Liu in their Research Article (e16095).
Fields of Study & Subjects
Advanced biosensing and bioanalysis techniques
DNA and Nucleic Acid Chemistry
Supramolecular Chemistry and Complexes
Publication details
- Journal / source
- Angewandte Chemie International Edition
- Volume
- 65
- Issue
- 9
- Publication date
- 10 February 2026
- Language
- EN