Outside Back Cover: Unraveling Biomimetic Hydrogen Bonds of Dinucleotides by a Crown‐Ether‐Functionalized Tetraphenylethene‐Based Cage (Angew. Chem. Int. Ed. 11/2026)
Abstract
In the Research Article (e23981), Lin Cheng, Liping Cao, and co-workers designed and synthesized a crown-ether-functionalized tetraphenylethene-based cationic cage. This multi-cavity molecular cage establishes a multi-domain cooperative hydrophobic microenvironment that enhances hydrogen bonding among sequence-diverse dinucleotides in aqueous conditions. The study provides valuable insights into the sequence-dependent diversity of base hydrogen-bonding structures within artificial systems, potentially uncovering patterns that may also be present in nature.
Fields of Study & Subjects
Supramolecular Chemistry and Complexes
DNA and Nucleic Acid Chemistry
Advanced biosensing and bioanalysis techniques
Publication details
- Journal / source
- Angewandte Chemie International Edition
- Volume
- 65
- Issue
- 11
- Publication date
- 9 February 2026
- Language
- EN