Inside Back Cover: Programmable Antigen‐Specific Immunity via Self‐Adjuvanting Nanovaccines Co‐Delivering Immune Modulators (Angew. Chem. Int. Ed. 11/2026)

Angewandte Chemie International Edition 2026 Open access

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Authors: Keita Ito, Yoshiyuki Manabe, Shino Ohshima, Masatoshi Maeki, Manabu Tokeshi, Hiroshi Inaba, Kazunori Matsuura, Kazuya Kabayama, Yoshie Kametani, Koichi Fukase
DOI: 10.1002/anie.2026-m0402124700
Cited by: 0

Abstract

Self-adjuvanting vaccines—covalent conjugates of antigens and adjuvants—elicit robust antigen-specific immunity. In the Research Article (e20474), Yoshiyuki Manabe, Yoshie Kametani, Koichi Fukase, and co-workers formulated self-adjuvanting vaccines into cationic lipid nanoparticles (< 100 nm) incorporating supplemental adjuvants. These nanovaccines exhibited potent immunogenicity in humanized mouse models, underscoring their translational potential for cancer immunotherapy.

Fields of Study & Subjects

Immunotherapy and Immune Responses Nanoparticle-Based Drug Delivery Immune responses and vaccinations

Publication details

Journal / source
Angewandte Chemie International Edition
Volume
65
Issue
11
Publication date
15 February 2026
Language
EN