Outside Front Cover: Surface Avidity of Anionic Polypeptide Coatings on Layer‐by‐Layer Nanoparticles Target Cancer‐Associated Amino Acid Transporters (Angew. Chem. Int. Ed. 8/2026)

Angewandte Chemie International Edition 2026 Open access

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Authors: Ivan Susin Pires, Margaret M. Billingsley, Ezra Gordon, Andrew J. Pickering, Eva Cai, Gonzalo J. Esparza, Mae L. Pryor, Alexander D. Stoneman, Aidan Kindopp, Darrell J. Irvine, Paula Therese Hammond
DOI: 10.1002/anie.2026-m1001093800
Cited by: 0

Abstract

In their Research Article (e19203), Darrell J. Irvine, Paula T. Hammond, and co-workers uncover that the dense presentation of anionic amino-acid motifs on layer-by-layer nanoparticles (green) enables selective recognition of amino-acid transporters on cancer cells (pink; blue nucleus; white indicates NP–receptor colocalization). These findings define a transporter-targeting mode of action for a nanoparticle delivery platform with demonstrated preclinical activity.

Fields of Study & Subjects

Nanoparticle-Based Drug Delivery RNA Interference and Gene Delivery Dendrimers and Hyperbranched Polymers

Publication details

Journal / source
Angewandte Chemie International Edition
Volume
65
Issue
8
Publication date
14 January 2026
Language
EN