Inside Back Cover: Coumarin‐30 Enables Site‐Resolved Detection of Tubulin Ligands by Microscale Thermophoresis (Angew. Chem. Int. Ed. 12/2026)

Angewandte Chemie International Edition 2026

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Authors: Mikhail N. Anisimov, Maksim A Boichenko, Anton A. Sivachev, Alexey N. Romanov, Ilya A. Lifshits, Julia N. Borzunova, Marina Janibekova, Vadim V. Mustyatsa, Timur P. Tikhonov, Andrey Yu. Plodukhin, Vitaly V. Shorokhov, Victor A. Tafeenko
+11 more Nina K Ratmanova, Sergey S Zhokhov, Роман А. Новиков, Olga I. Kechko, Alexander А. Makarov, Vladimir A. Mitkevich, Ivan A Andreev, Ivan A. Vorobjev, Igor V. Trushkov, Olga A. Ivanova, Никита Борисович Гудимчук
DOI: 10.1002/anie.2026-m1902093200
Cited by: 0

Abstract

In the Research Article (e17086), Igor V. Trushkov, Olga A. Ivanova, Nikita B. Gudimchuk, and co-workers establish coumarin-30 as a new versatile fluorescent probe for tubulin, enabling site-resolved detection of diverse ligands. The cover presents an artistic scene in which coumarin-30 casts light onto a tubulin dimer suspended in a deep-water environment. Four colored ligands appear bound to the protein, while their chemical structures emerge as corals growing on the shadow, each arising from a distinct binding site. Art by M. Andreeva.

Fields of Study & Subjects

Field-Flow Fractionation Techniques Microtubule and mitosis dynamics Molecular Sensors and Ion Detection

Publication details

Journal / source
Angewandte Chemie International Edition
Volume
65
Issue
12
Publication date
5 March 2026
Language
EN