Frontispiece: Spatial Mapping of Membrane Protein Interactions Using a DNA Origami Rubbing

Angewandte Chemie International Edition 2026

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Authors: Qian Tang, Huanglei Yu, Jianing Hou, Meng Jiang, Zhiming Zhang, Junyan Wang, Mingzhi Zhang, Da Han, Pei Guo
DOI: 10.1002/anie.2026-m2402081700
Cited by: 0

Abstract

A strategy named DNA origami rubbing (DOR) was developed for 2D mapping of protein-protein interactions (PPIs) in cell membrane using DNA origami technology and DNA polymerase-mediated strand-elongation, mimicking making stone rubbing with rice paper and graphite. The results showed that DOR can map the fluctuation of 2D distribution of proteins induced by ligands, demonstrating its feasibility for revealing novel PPIs and making it a potential tool for disease screening and predicting medical treatment outcomes. More in the Research Article (e13795), Da Han, Pei Guo, and co-workers.

Fields of Study & Subjects

Advanced biosensing and bioanalysis techniques Lipid Membrane Structure and Behavior DNA and Biological Computing

Publication details

Journal / source
Angewandte Chemie International Edition
Volume
65
Issue
12
Publication date
16 March 2026
Language
EN