Lewis Base‐Catalyzed DYKAT of Racemic Chlorohydrosilanes With Grignard Reagents En Route to Si ‐Stereogenic Hydrosilanes

Angewandte Chemie International Edition 2026

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Authors: Yulang Tang, Qi Zhou, Shuya Li, Tianbao Hu, Yuzhong Kuang, Qin Li, Yanqian Xie, Mingyuan Yin, Lu Gao, Wanshu Wang, Zhishan Su, Zhenlei Song
DOI: 10.1002/anie.3901082
Cited by: 3
References: 72

Abstract

Enantioenriched hydrosilanes bearing a Si-stereogenic center have garnered considerable attention due to the relevance in diverse areas of organic chemistry. Their synthesis has predominantly been limited to stereospecific reduction of chiral silylethers or silazanes, or catalytic desymmetrization of prochiral dihydrosilanes. Herein, we disclose a mechanistically distinct strategy: a (S, R)-benzotetramisole-catalyzed dynamic kinetic asymmetric transformation (DYKAT) of racemic chlorohydrosilanes with Grignard reagents. The method enables enantioconvergent Si*─C bond formation, giving Si-stereogenic hydrosilanes-many of which are challenging to access via desymmetrization-in high yields and with high enantioselectivity (34 examples, up to 99% yield, 99:1 er).

Fields of Study & Subjects

Organoboron and organosilicon chemistry Synthesis and characterization of novel inorganic/organometallic compounds Radical Photochemical Reactions

Publication details

Journal / source
Angewandte Chemie International Edition
Publisher
Wiley
Volume
65
Issue
14
Pages
e3901082–e3901082
Publication date
21 February 2026
Language
EN