Modular Access to Nitriles From Carbonyls via Deoxygenative Transformation With Polarity Inversion

Angewandte Chemie International Edition 2026

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Authors: Fancong Meng, Wenying Xu, Zheng Wang, Yuanqiang Chen, Xia Ss, Tao XU
DOI: 10.1002/anie.8039232
Cited by: 4
References: 49

Abstract

The C─O bond cleavage has always been a central challenge for deoxygenation due to high bond dissociation energies. Here, we develop a Lewis acid-promoted polarity inversion strategy that enables a strong C─O bond cleavage and rapid access to nitriles from carbonyls. Its broad applicability, together with the nontoxic and mild conditions, underscores the highly modular nature of this method.

Fields of Study & Subjects

Catalytic C–H Functionalization Methods Advanced Synthetic Organic Chemistry Catalytic Cross-Coupling Reactions

Publication details

Journal / source
Angewandte Chemie International Edition
Publisher
Wiley
Volume
65
Issue
13
Pages
e8039232–e8039232
Publication date
17 February 2026
Language
EN