Palladium‐Catalyzed β − Carbonyl Alkylation of α ‐Imino Esters With Allylic/Propargyl Alcohols
Abstract
ABSTRACT A palladium‐catalyzed β ‐carbonyl alkylation of α ‐imino esters with readily available allylic/propargyl alcohols has been developed, enabling efficient synthesis of structurally diverse δ ‐carbonyl‐ α ‐amino acid esters and carbonyl‐containing pyrrolidine derivatives. Mechanistic studies indicate that the reaction proceeds via a dehydrogenation‐Michael addition or [3 + 2] cyclization pathway. This method offers an atom‐economical and operationally straightforward strategy for the synthesis of highly functionalized Δ(1)‐pyrrolines and pyrrolidines.
Fields of Study & Subjects
Catalytic Alkyne Reactions
Catalytic C–H Functionalization Methods
Asymmetric Hydrogenation and Catalysis
Publication details
- Journal / source
- Applied Organometallic Chemistry
- Volume
- 40
- Issue
- 2
- Publication date
- 8 January 2026
- Language
- EN