Iridium‐Catalyzed C–H Silylation of Indoles With Hydrosilanes in Aqueous Media

Applied Organometallic Chemistry 2026

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Authors: Jingyi Zhan, Xinni Tang, Xuyao Zhong, Wenjie Hu, Lei Yang
DOI: 10.1002/aoc.70536
Cited by: 2
References: 73

Abstract

ABSTRACT Herein, we report that directed C–H silylation of indoles and a pyrrole derivative with hydrosilanes in aqueous media under air was achieved under iridium catalysis. This reaction enables the introduction of a silyl group at the C2 position of a wide range of indoles. The protocol represents the first example of a transition metal‐catalyzed C–H silylation in aqueous media as a sustainable solvent for C–H functionalization of indoles.

Fields of Study & Subjects

Catalytic C–H Functionalization Methods Catalytic Cross-Coupling Reactions Cyclopropane Reaction Mechanisms

Publication details

Journal / source
Applied Organometallic Chemistry
Publisher
Wiley
Volume
40
Issue
3
Publication date
9 February 2026
Language
EN