Palladium‐Catalyzed Decarboxylative C─H Alkenylation of Proaromatic Acids With Allyl Alcohols and N ‐Allyl Sulfonamides

Chemistry - An Asian Journal 2026 Open access

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Authors: Yin‐Chia Lu, Veerabhushanam Kadiyala, Prahallad Meher, Yu‐Ying Chuang, Gottam Sreenivasulu, Sandip Murarka, Chih‐Ming Chou
DOI: 10.1002/asia.202500877
Cited by: 0
References: 33

Abstract

We develop an efficient palladium-catalyzed decarboxylative C─H alkenylation of cyclohexa-2,5-dienyl carboxylic acids with allylic alcohols and N-allyl sulfonamides, enabling regioselective access to diverse vinylarenes. The transformation proceeds under mild, operationally simple conditions and tolerates a broad range of alkyl, aryl, and heteroaryl substituents. Mechanistic studies reveal that the reaction is going via carboxylate-directed C─H activation and olefin insertion step. The method is scalable and offers a practical route to vinylarene scaffold-containing biologically relevant moieties.

Fields of Study & Subjects

Catalytic C–H Functionalization Methods Catalytic Cross-Coupling Reactions Oxidative Organic Chemistry Reactions

Publication details

Journal / source
Chemistry - An Asian Journal
Volume
21
Issue
1
Pages
e00877–e00877
Publication date
1 January 2026
Language
EN