Construction of the Pentacyclic Core of Yohimbine Alkaloids: A Chemoenzymatic Approach
Abstract
An enantiodivergent route was devised for accessing the two enantiomers of indolo[2,3-a]quinolizidine, which serve as a platform for the synthesis of Corynanthe alkaloids with dimorphic configurations at the C3 position. The cascade process, involving dipolar cycloaddition, N-O bond cleavage, and cyclization, minimizes the need for functional group elaboration. Subsequent alkylation, allylation, and ring-closing metathesis smoothly constructed the pentacyclic ring system embedded in yohimbine alkaloids. The inherent simplicity and efficiency of enzymatic kinetic resolution prove valuable for diverse structural derivatives.
Fields of Study & Subjects
Advanced Synthetic Organic Chemistry
Alkaloids: synthesis and pharmacology
Chemical synthesis and alkaloids
Publication details
- Journal / source
- Chemistry - An Asian Journal
- Volume
- 21
- Issue
- 1
- Pages
- e01002–e01002
- Publication date
- 1 January 2026
- Language
- EN