Pyridine and N ‐Pyridinium Functionalized Macrocyclic Squaramide Anion Receptors with High Affinity for Aqueous Sulfate
Abstract
Macrocyclic squaramide-containing receptors have previously been shown to bind sulfate with high selectivity and affinity in aqueous-organic mixtures. To increase binding affinity of this class of hydrogen-bonding receptors in pure water, macrocycles in which pyridinium groups have been inserted to provide additional charge-assisted hydrogen-bonding interactions were synthesized and their anion binding evaluated. The inclusion of charge-assisted interactions provides enhanced binding affinity for sulfate in water but concomitantly reduces ability of the receptors to discriminate sulfate from the closely related selenate and leads to unexpected changes in binding stoichiometry.
Fields of Study & Subjects
Molecular Sensors and Ion Detection
Supramolecular Chemistry and Complexes
Crystallography and molecular interactions
Publication details
- Journal / source
- Chemistry - An Asian Journal
- Publisher
- Wiley
- Volume
- 21
- Issue
- 1
- Pages
- e70547–e70547
- Publication date
- 1 January 2026
- Language
- EN