Electro‐ and Mechanochemical C(sp 2 )‐H Chalcogenations of 4‐Hydroxycoumarins/4‐Hydroxy‐ N ‐methylquinolin‐2‐one: A Dual Green Synthetic Approach
Abstract
We report two distinct and complementary synthetic strategies-electrochemical and mechanochemical-for the preparation of diversely functionalized chalcogenated 4-hydroxycoumarins/4-hydroxy-N-methylquinolin-2-one. Each method provides a practical and straightforward route to biologically relevant sulfide- and selenide-functionalized oxygen- and nitrogen-containing heterocycles. The developed protocols offer multiple advantages, including mild and energy-efficient reaction conditions, the elimination of transition-metal catalysts, the use of external heating and additional oxidants, short reaction times, high to excellent yields, a broad substrate scope, gram-scale applicability, operational simplicity, and environmentally friendly execution. Additionally, the synthetic application of the synthesized compounds has been extended.
Fields of Study & Subjects
Sulfur-Based Synthesis Techniques
Radical Photochemical Reactions
Organoselenium and organotellurium chemistry
Publication details
- Journal / source
- Chemistry - An Asian Journal
- Publisher
- Wiley
- Volume
- 21
- Issue
- 11
- Pages
- e70828–e70828
- Publication date
- 1 June 2026
- Language
- EN