Development of a population pharmacokinetic model using combined paediatric and adult data for four pulmonary arterial hypertension drugs

British Journal of Clinical Pharmacology 2026 Open access

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Authors: Motoyasu Miura, Shimako Tanaka, Ririka Aihara, Shun Yamamoto, Yasumi Nakashima, Yasuharu Kashiwagura, Akio Hakamata, Sachiko Miyakawa, Mariko Tatsuguchi, Keiichi Odagiri, Noriyuki Namiki, Naoki Inui
+2 more Hiroshi Watanabe, Shinya Uchida
DOI: 10.1002/bcp.70676
Cited by: 1
References: 23

Abstract

Aims Pulmonary arterial hypertension (PAH) is a syndrome characterized by elevated pulmonary artery pressure. We developed a population pharmacokinetic (PPK) model using combined plasma drug concentration data from Japanese paediatric (

Fields of Study & Subjects

Pulmonary Hypertension Research and Treatments Phosphodiesterase function and regulation Blood Pressure and Hypertension Studies

Publication details

Journal / source
British Journal of Clinical Pharmacology
Publisher
Wiley
Volume
92
Issue
10
Pages
3611-3621
Publication date
1 July 2026
Language
EN