Homologous tumor‐targeting biomimetic nanozyme for synergistic NIR‐II photothermal and chemodynamic therapy

Abstract The therapeutic potential of nanozyme‐mediated chemodynamic therapy (CDT) is often hindered by limited catalytic efficiency and undesirable off‐target effects. To address these limitations, we engineered a cancer cell membrane‐coated Au‐MnO x nanozyme (Au‐MnO x @CCM) engineered for near‐infrared (NIR) enhanced tumor CDT. This multifunctional nanozyme exhibits both catalase‐like (CAT‐like) and peroxidase‐like (POD‐like) activities, enabling the in situ generation of oxygen (O 2 ) to alleviate tumor hypoxia and facilitate the production of cytotoxic hydroxyl radicals (•OH) for selective tumor cell eradication. Concurrently, the Au‐MnO x nanozyme effectively depletes intracellular glutathione (GSH), thereby amplifying oxidative stress and enhancing CDT efficacy. The biomimetic coating with homologous the cancer cell membrane (CCM) significantly improves tumor‐targeting specificity, reduces off‐target accumulation, prolongs systemic circulation, and minimizes immune clearance. Moreover, the application of NIR irradiation enables deep tissue penetration and precise spatial activation of the nanozyme at the tumor site, further enhancing therapeutic selectivity and potency. Collectively, this well‐designed Au‐MnO x @CCM nanozyme integrates CDT and photothermal therapy (PTT), offering a synergistic, tumor‐specific, and minimally invasive therapeutic strategy. This platform holds considerable promise for advancing precision oncology with improved therapeutic outcomes and reduced systemic toxicity.