A PVA /chitosan/gelatin scaffold incorporating salicylic acid‐loaded TiO ₂ nanoparticles enhances collagen I expression and accelerates cutaneous wound repair in mice
Abstract
Wound healing is a complex biological process requiring coordinated cellular and molecular responses, motivating the development of bioactive scaffolds capable of modulating the wound microenvironment. In this study, a nanocomposite scaffold composed of chitosan, polyvinyl alcohol (PVA), and gelatin incorporating salicylic acid-loaded titanium dioxide nanoparticles (TiO₂ NPs) was fabricated and evaluated for wound-healing applications. TiO₂ nanoparticles synthesized via a co-precipitation method exhibited nanoscale dimensions, high crystallinity, a negative surface charge (-19.4 mV), and a drug-loading efficiency exceeding 90%. The scaffold showed good structural integrity under physiological conditions, excellent hemocompatibility (
Fields of Study & Subjects
Wound Healing and Treatments
Collagen: Extraction and Characterization
Surgical Sutures and Adhesives
Publication details
- Journal / source
- Biotechnology Progress
- Publisher
- Wiley
- Volume
- 42
- Issue
- 4
- Pages
- e88500–e88500
- Publication date
- 5 May 2026
- Language
- EN