Phomones A−C, Anti‐ Vibrio α ‐Pyrones From Phoma sp. NBUF235 Associated With an Ircinia Sponge From the Marine Mesophotic Zone
Abstract
Three new α-pyrones, named as phomones A-C (1-3), together with three known analogs (4-6), were isolated from the fungus Phoma sp. NBUF235 associated with an Ircinia sp. sponge collected from the marine mesophotic zone. The discovery of these compounds was facilitated by bioassay-guided isolation. Structural elucidation of these compounds was achieved through comprehensive spectroscopic analysis, and quantum chemistry calculations. Compounds 1-6 selectively inhibited the aquatic pathogenic bacteria Vibrio harveyi, V. parahaemolyticus, V. fluvialis, V. furnissii, V. mimicus, and V. cholerae (Non-O1 strain), with MIC values ranging from 8 to 32 µg/mL. These findings enrich the chemical diversity of α-pyrones from sponge-associated fungi in the marine mesophotic zone, providing promising molecules for the development of anti-Vibrio agents.
Fields of Study & Subjects
Marine Sponges and Natural Products
Microbial Natural Products and Biosynthesis
Seaweed-derived Bioactive Compounds
Publication details
- Journal / source
- Chemistry & Biodiversity
- Publisher
- Wiley
- Volume
- 23
- Issue
- 3
- Pages
- e02573–e02573
- Publication date
- 1 March 2026
- Language
- EN