ImesAgCl/TBHP Promoted Aqueous Synthesis of Isatin‐Amide Derivatives: Anti‐proliferative, Anti‐Vascular Endothelial Growth Factor Receptor 2, Bioavailability and Molecular Docking Studies

ABSTRACT Cancer is a worldwide health burden that influences about every geographic location and socioeconomic class. One of the main challenges that remains is the appearance of resistance to cancer therapy. It is found that vascular endothelial growth factor receptor 2 (VEGFR‐2) is overexpressed in a number of tumours. Few FDA approved drugs (such as Sorafenib, Sunitinib, Nintedanib and Cabotanzinib), which target VEGFRs, however, a significant issue with the monotherapy of these agents is drug resistance. Hence, in the present work. Some isatin‐aromatic amides ( 5a–q ) were synthesised via Ag(I)‐NHC/TBHP‐promoted tandem one‐pot oxidative amidation between 3‐((3‐hydroxypropyl)imino)‐1‐methylindolin‐2‐one ( 3 ) and anilines ( 4a–q ) in water as a key approach. The anti‐proliferative activity of amides ( 5a–q ) revealed that compound 5j (50% inhibitory concentration [IC 50 ] =