Placidenes G–J, Bioactive γ ‐Pyrone Derivatives From the Marine Mollusk Placida dendritica
Abstract
Three pairs of undescribed enantiomeric γ-pyrone derivatives placidenes G-I (1-3), together with two new congeners placidene J (4)/isoplacidene J (5) and two known compounds 6 and 7, were isolated from the marine mollusk Placida dendritica. Compounds 1a/1b-3a/3b were further separated by chiral-phase high-performance liquid chromatography. The structures were elucidated by comprehensive spectroscopic analysis, high-resolution electrospray ionization mass spectrometry, time-dependent density functional theory/electronic circular dichroism calculation, and X-ray diffraction analysis. In bioassays, compounds 1-5 exhibited moderate nitric oxide inhibition from 28.2% to 51.9% on RAW264.7 inflammatory cells at 20 µM without notable cytotoxicity.
Fields of Study & Subjects
Marine Sponges and Natural Products
Synthetic Organic Chemistry Methods
Microbial Natural Products and Biosynthesis
Publication details
- Journal / source
- Chemistry & Biodiversity
- Volume
- 23
- Issue
- 1
- Pages
- e03208–e03208
- Publication date
- 1 January 2026
- Language
- EN