Unveiling the Leishmanicidal Mechanism of 4‐Nerolidylcatechol Isolated From Piper peltatum Against Leishmania infantum

Chemistry & Biodiversity 2026 Open access

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Authors: Fabiana Brusco Lorenzetti, Rodolfo Bento Balbinot, Danielle Lazarin‐Bidóia, Viviane dos Santos Faiões, Eduardo Caio Torres-Santos, Celso Vataru Nakamura, Tânia Ueda‐Nakamura, D Aparício Garcia Cortez, Benedito Prado Dias Filho
DOI: 10.1002/cbdv.202503244
Cited by: 1
References: 39

Abstract

The present study assessed the leishmanicidal activity of 4-nerolidylcatechol (4-NC) (1) isolated from Piper peltatum leaves against promastigotes and amastigotes of Leishmania amazonensis, L. braziliensis, and L. infantum. The plant was fractionated, leading to the isolation and chemical identification of 4-NC (1). Biochemical techniques were subsequently employed to investigate the mechanism of action of both the extract and the compound. The induction of cellular apoptosis through reactive oxygen species production appears to be a predominant mechanism of action. In addition, both 4-NC (1) and the hydroethanolic extract showed minimal toxicity to human cells, even at higher concentrations. To our knowledge, this study represents the first report highlighting the leishmanicidal properties of 4-NC (1).

Fields of Study & Subjects

Research on Leishmaniasis Studies Piperaceae Chemical and Biological Studies Insect Pest Control Strategies

Publication details

Journal / source
Chemistry & Biodiversity
Publisher
Wiley
Volume
23
Issue
1
Pages
e03244–e03244
Publication date
1 January 2026
Language
EN