Four New Phenolic Glycosides From the Roots of Ilex pubescens and Their Cardioprotective Effects
Abstract
Four undescribed phenolic glycosides, pubescenosides V-Y (1-4), and nine known compounds (5-13) were isolated from the roots of Ilex pubescens. Structural elucidation was performed using various techniques, including infrared spectroscopy, ultraviolet spectroscopy, high-resolution electrospray ionization mass spectrometry, electronic circular dichroism spectroscopy, and nuclear magnetic resonance spectroscopy. The cardioprotective effects of the compounds were evaluated using an oxygen-glucose deprivation-induced injury model in H9c2 cells. At 10 µM, all compounds were nontoxic; however, compounds 5 and 12 significantly increased the cell viability, positioning them as promising lead compounds for cardioprotective drug development.
Fields of Study & Subjects
Phytochemistry and Biological Activities
Magnolia and Illicium research
Traditional Chinese Medicine Analysis
Publication details
- Journal / source
- Chemistry & Biodiversity
- Volume
- 23
- Issue
- 3
- Pages
- e03550–e03550
- Publication date
- 1 March 2026
- Language
- EN